Investigating Eukaryotic Elongation Factor 2 Kinase/Eukaryotic Translation Elongation Factor 2 Pathway Regulation and Its Role in Protein Synthesis Impairment during Disuse-Induced Skeletal Muscle Atrophy.

Vilchinskaya N., Lim WF., Belova S., Roberts TC., Wood MJA., Lomonosova Y.

The principal mechanism underlying the reduced rate of protein synthesis in atrophied skeletal muscle is largely unknown. Eukaryotic elongation factor 2 kinase (eEF2k) impairs the ability of eukaryotic translation elongation factor 2 (eEF2) to bind to the ribosome via T56 phosphorylation. Perturbations in the eEF2k/eEF2 pathway during various stages of disuse muscle atrophy have been investigated utilizing a rat hind limb suspension (HS) model. Two distinct components of eEF2k/eEF2 pathway misregulation were demonstrated, observing a significant (P 

DOI

10.1016/j.ajpath.2023.02.009

Type

Journal

Am J Pathol

Publication Date

06/2023

Volume

193

Pages

813 - 828

Keywords

Rats, Animals, Elongation Factor 2 Kinase, Peptide Elongation Factor 2, Phosphorylation, Muscle, Skeletal, Muscular Atrophy, Ribosomal Protein S6 Kinases

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