A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles

Garcia-Guerra A., Ellerington R., Gaitzsch J., Bath J., Kye M., Varela MA., Battaglia G., Wood MJA., Manzano R., Rinaldi C., Turberfield AJ.

Polymeric spherical nucleic acids comprise pH-sensitive, polymer-conjugated oligonucleotides that self-assemble into nanoparticles with the ability to escape endosomes, overcoming a major obstacle in nucleic acid delivery.

DOI

10.1039/d2na00846g

Type

Journal article

Journal

Nanoscale Advances

Publisher

Royal Society of Chemistry (RSC)

Publication Date

2023

Permalink Original publication