Thomas Roberts
Senior Post Doctoral Researcher/Team Leader
Tom Roberts is a senior research scientist in the Department of Paediatrics where he leads a team with the overall theme of ‘RNA medicine’. His research interests include neuromuscular disorders, RNA biology, extracellular nucleic acids, biomarkers, epigenetics, and gene/oligonucleotide therapies. Tom studied at the University of Oxford for both his undergraduate degree in Molecular and Cellular Biochemistry and doctoral degree in Physiology, Anatomy and Genetics (thesis title: Duchenne Muscular Dystrophy: RNA-based therapeutics and microRNA biology). He subsequently moved to San Diego, California where he undertook postdoctoral training positions at the Scripps Research Institute, Department of Molecular and Experimental Medicine (laboratory of Professors Kevin Morris and Marc Weinberg) and Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program (laboratory of Professor Lorenzo Puri). He later returned to the University of Oxford, Department of Paediatrics where he re-joined the Wood group
Recent publications
Myonuclear Domain-Associated and Central Nucleation-Dependent Spatial Restriction of Dystrophin Protein Expression.
Journal article
Chwalenia K. et al, (2026), J Cachexia Sarcopenia Muscle, 17
Targeted BDNF upregulation via upstream open reading frame disruption.
Journal article
Feng N. et al, (2026), Mol Ther, 34, 1652 - 1671
Timing matters: exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy
Preprint
Stenler S. et al, (2025)
Progress and prospects in antisense oligonucleotide-mediated exon skipping therapies for Duchenne muscular dystrophy.
Journal article
Chwalenia K. et al, (2025), J Muscle Res Cell Motil, 46, 293 - 300
AAV microdystrophin gene replacement therapy for Duchenne muscular dystrophy: progress and prospects.
Journal article
Chwalenia K. et al, (2025), Gene Ther, 32, 447 - 461
