Britt Hanson
DPhil Student
My DPhil project is largely focused on applying CRISPR/Cas9 genome engineering for the molecular correction of Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA). In addition to this, I am working on developing combination therapies for such neuromuscular disorders whereby the muscle architecture is stabilised and the genetic cause of the disease can be targeted simultaneously.
Recent publications
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Molecular correction of Duchenne muscular dystrophy by splice modulation and gene editing.
Journal article
Hanson B. et al, (2021), RNA Biol, 1 - 15
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Application of CRISPR-Cas9-Mediated Genome Editing for the Treatment of Myotonic Dystrophy Type 1.
Journal article
Marsh S. et al, (2020), Mol Ther, 28, 2527 - 2539
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Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy.
Journal article
van Westering TLE. et al, (2020), Mol Cell Proteomics, 19, 2047 - 2068
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Mutation-independent proteomic signatures of pathological progression in murine models of Duchenne muscular dystrophy.
Journal article
van Westering TLE. et al, (2020), Mol Cell Proteomics
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Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics.
Journal article
Coenen-Stass AML. et al, (2019), RNA Biol, 16, 696 - 706