Catheryn Wooi Lim
Post Doctoral Researcher
Post Doctoral Scientist
I completed my Ph.D. program at University of New South Wales, Australia in transcription factor biology under the mentorship of Professor Merlin Crossley in 2016, where I studied the design of artificial DNA binding factors and investigated how transcription factors find their targets in vivo. I joined Matthew’s group in 2017 as a postdoctoral research scientist in muscle biology. Here I am studying transcriptional regulators involved in muscle regeneration and in collaboration with Dr. Carlo Rinaldi, I am also investigating the role of an androgen receptor isoform in the pathogenesis of Spinal bulbar muscular atrophy (SBMA).
Recent publications
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice.
Journal article
Prakasam R. et al, (2023), Nat Commun, 14
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Journal article
Baker YR. et al, (2022), Nat Commun, 13
AR cooperates with SMAD4 to maintain skeletal muscle homeostasis.
Journal article
Forouhan M. et al, (2022), Acta Neuropathol, 143, 713 - 731
Oligonucleotide analogues with locked-amide linkages have therapeutic potential
Preprint
Baker Y. et al, (2022)
Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.
Journal article
Dar GH. et al, (2021), Nat Commun, 12