Catheryn Wooi Lim
Post Doctoral Researcher
Post Doctoral Scientist
I completed my Ph.D. program at University of New South Wales, Australia in transcription factor biology under the mentorship of Professor Merlin Crossley in 2016, where I studied the design of artificial DNA binding factors and investigated how transcription factors find their targets in vivo. I joined Matthew’s group in 2017 as a postdoctoral research scientist in muscle biology. Here I am studying transcriptional regulators involved in muscle regeneration and in collaboration with Dr. Carlo Rinaldi, I am also investigating the role of an androgen receptor isoform in the pathogenesis of Spinal bulbar muscular atrophy (SBMA).
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice.
Prakasam R. et al, (2023), Nat Commun, 14
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Baker YR. et al, (2022), Nat Commun, 13
AR cooperates with SMAD4 to maintain skeletal muscle homeostasis.
Forouhan M. et al, (2022), Acta Neuropathol, 143, 713 - 731
Oligonucleotide analogues with locked-amide linkages have therapeutic potential
Baker Y. et al, (2022)
Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain.
Dar GH. et al, (2021), Nat Commun, 12