Carlo Rinaldi
ASSOCIATE PROFESSOR Wellcome Trust Clinician Scientist , Honorary Consultant Neurologist
My overall research interest is the application of genetic knowledge to benefit human health. This goal is pursued through three strategic aims: (1) identification of genes associated with neurological diseases, (2) advancement of the current understanding of the molecular mechanisms of pathogenesis in these diseases, and (3) development of effective treatments for hereditary neurological diseases.
Recent publications
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Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs.
Garcia-Guerra A. et al, (2025), Nucleic Acids Res, 53
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Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs
Garcia-Guerra A. et al, (2024)
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PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.
Kordala AJ. et al, (2023), EMBO Mol Med, 15
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A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles
Garcia-Guerra A. et al, (2023), Nanoscale Advances
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Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.
Kandasamy P. et al, (2022), Nucleic Acids Res, 50, 5443 - 5466